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Repair of DNA double strand breaks (DSBs) was also assessed along with expressions of DSB repair-related proteins.Cell cycle analysis after the combined treatment was also performed.The more intensified G2 cell cycle delay was also associated with the combined treatment when compared with carbon ion treatment alone.Our findings indicate that the combination of Hsp90 inhibition and heavy-ion irradiation provides a new effective therapeutic alternative for treatment of solid tumors.
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Hsp90 inhibitors have become well-studied antitumor agents for their selective property against tumors versus normal cells.
The combined treatment of Hsp90 inhibitor and conventional photon radiation also showed more effective tumor growth delay than radiation alone.
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